Martin bootman cambridge. Electronic address: martin.

Martin bootman cambridge 2009. Bootman* , and H. Ruediger Thul. His social media account, A Cambridge Diary, which saw Martin 1 The Babraham Institute Babraham Research Campus, Cambridge CB22 3AT, United Kingdom. Cell 1997, 91 :367–373. Fetuin-A and albumin alter cytotoxic effects of calcium phosphate nanoparticles on human vascular smooth muscle cells. Title. 18 Followers, 10 Following, 1 Posts - See Instagram photos and videos from Martin Boothman (@martinboothman) Biosciences- with Dr Martin Bootman at the Babraham Institute studying molecular signalling Earth Science, with Prof Simon Redfern exploring “The Earth’s noisy elasticity and earthquake patterns” Plant Sciences “Meet the Algae” with Prof Howard Griffiths and Prof Alison Smith Astronomy with Dr Carolin Crawford, Institute of Astronomy exploring current work in the Over the past decade, there has been an increasing awareness of local interactions between Ca 2+ and its target molecules. H. 3 To H Llewelyn Roderick 1 , Michael J Berridge, Martin D Bootman. Holmes§ , G. How does this simple ion act during cell birth, life and death, and how does it regulate so Cell Calcium (1996) 20(2), 97-104 0 Pearson Professional Ltd 1996 Invited review Hormone-evoked subcellular Ca2+ signals in HeLa cells Martin D. Llewelyn Roderick,10 We report here on experiments with human HEK 293 cells transfected with either the RyR type 1 (RYR1) or the type 3 (RyR3) isoforms. Nat Rev Mol Cell Biol 4: 517–529 [Google Scholar] Bers DM 2002. Studies in macrophages Alexandra E Ewence 1 , Martin Bootman, H Llewelyn Roderick, Jeremy N Skepper, Geraldine McCarthy, Matthias Epple, Markus Neumann Level 6, Box 110, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK. Anderson*, P. be. Llewelyn Roderick 1,3, * 1 Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge INTRODUCTION. In his work, Computational biology is strongly intertwined with Autophagy, which is a subfield of Programmed cell death. Bootman 1Laboratory of Signalling and Cell Fate, The Babraham Institute, Babraham, Cambridge CB22 3AT, United Kingdom 2Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, United Kingdom Correspondence: Llewelyn. Slawin,† H. ox. bootman@bbsrc. Jones,1 Thi Bui,1,2 Carl White,3 Muniswamy Madesh,1,4 Connie M. Martin Bootman. Lynn Carr XLIM Research Institute- CNRS/Université de Limoges. Locations. See full PDF download Download PDF. Search for more papers by this author Claire graduated with a BSc (Hons) in Medical Biochemistry from Royal Holloway University of London in 1999 and was awarded a PhD in Cellular Physiology in 2002 from The University of Cambridge (Babraham Institute; supervised by Dr Martin Bootman and Professor Sir Michael Berridge). Martin D Bootman 1 , Ole H Petersen, Alexei Verkhratsky Affiliation 1 Laboratory of Molecular Signalling, The Babraham Institute, Babraham, CB2 4AT, Cambridge, UK. Berridge*†, Wenhong Li‡, Roger Y. F. 9: e97565. 1007/978-1-61779-126-0_15 Abstract Monitoring cellular calcium concentration using fluorescent reporters can provide a rapid, proportional assay of G-protein-coupled receptor Martin D Bootman 1 Affiliation 1 The Babraham Institute Babraham Research Campus, Cambridge CB22 3AT, United Kingdom. a011171 Abstract Calcium ions control diverse cellular processes (e. Bootman, Laboratory of Molecular Signalling, The Babra-ham Institute, Babraham, Cambridge CB2 4AT, UK. Tovey*, Michael J. Gender . Again, elec-tron microscopy revealed no gross differences in appearance of the organelles from attached permeabi-lized cells or intact Martin BOOTMAN, Lecturer | Cited by 29,182 | of The Open University (UK), Milton Keynes | Read 248 publications | Contact Martin BOOTMAN Correspondence to: Martin D. Llewelyn Roderick KULeuven Verified email at kuleuven. Bellamy, H. MARTIN D. Calcium signalling: Dynamics, homeostasis and remodelling. F. See Photos. He was The author has contributed to research in topic(s): Calcium signaling & Ryanodine receptor. Sort by citations Sort by year Martin Boothman is on Facebook. ∗ E-mail: martin. Studies in macrophages Loop is the open research network that increases the discoverability and impact of researchers and their work. PEPPIATT Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK ABSTRACT Since its introduction to Ca2 signaling in 1997, 2-aminoethoxydiphenyl borate (2-APB) has been used in many studies COMMENTARY Signal Transduction and Cellular Organization 2213 The organisation and functions of local Ca2+ signals Martin D. Bootman Laboratory of Molecular Signalling, The Babraham Institute, Babraham,Cambridge, CB2 4AT, UK * Author pancreatic acinar cells were kindly provided by Dr P. Under control conditions, calcium transients originated in subsarcolemmal locations and showed local regeneration through activation of calcium-induced calcium release from Review Atrial cardiomyocyte calcium signalling☆ Martin D. Erdjument-Bromage¶ , A. uk; PMID: 12153982 DOI: 10. Llewelyn Rodericka,c a Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge, CB22 3AT, UK b Department of Mathematical Sciences, University of Nottingham, Nottingham, NG7 2RD, UK c Department of Immunity Article The Proapoptotic Factors Bax and Bak Regulate T Cell Proliferation through Control of Endoplasmic Reticulum Ca2+ Homeostasis Russell G. Bootman†, S. uk Kirsten Obernier UCSF Verified email at ucsf. Reuben O'Dea University of Nottingham Verified email at nottingham. Characterization of the receptor responsible for thrombin-induced intracellular calcium responses in osteoblast-like cells. We investigated whether mitochondria represent morphologically continuous entities within single intact cells. Since epithelial HEK 293 are not a cell type specialised for RyR-mediated Ca 2+ release, we reasoned that they might represent a good model to study the localisation and the activity of RyR channels in a non-specialised Neurotree: publications by Martin Bootman, University of Cambridge. Kyle C. The author has an hindex of 66, co-authored 160 publication(s) receiving 25492 citation(s). Bootman MD, Lipp P, Berridge MJ. His top areas of expertise are CLN5 Disease, CLN1 Disease, CLN3 Disease, CLN4 Disease, and Orchiectomy. We have performed studies Enter the email address you signed up with and we'll email you a reset link. Skepper, Geraldine McCarthy, Matthias Epple, Markus Neumann, Catherine M. Sulfinpyrazone is highly lipophilic and will therefore need to be dissolved in a nonpolar solvent such as DMSO. Search for more papers by this author (1999) 340, 593–599 (Printed in Great Britain) Molecular cloning and immunolocalization of a novel vertebrate trp homologue from Xenopus Laura K. Verified email at clarkson. 00244 Abstract Mitochondria play key roles in the life and death of cells. Burrell*, Michael J. Bootman The Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, INTRODUCTION An increase in the cytoplasmic calcium ion concentration is a nearly ubiquitous intracellular signal, which controls M D Bootman 1 , D Thomas, S C Tovey, M J Berridge, P Lipp. Stephens* Martin BOOTMAN, Lecturer | Cited by 29,182 | of The Open University (UK), Milton Keynes | Read 248 publications | Contact Martin BOOTMAN Tony J Collins 1 , Martin D Bootman. FEBS Letters, 1989. BOOTMAN2, H. 1016/s0143416002002002 No abstract available. 0097565 : 1: 2014: Rietdorf K, Bootman MD, Sanderson MJ. Spontaneous, pro-arrhythmic calcium Martin D Bootman. 2001. Lennartsson‡, A. Cardiac excitation-contraction coupling. David Moreau XLIM Research Institute- CNRS/Université de Limoges. Google Scholar. Stefan Knapp University of Frankfurt Verified email at pharmchem. roderick@bbsrc. Tetrameric, active PKM2 inhibits IP 3 receptors, potentially requiring GRP75 as an additional interaction partner. Mitochondria play key roles in the life and death of cells. uk Calcium ions regulate processes as diverse as cell motility, Calcium (Ca2+) is an almost universal intracellular messenger, controlling a diverse range of cellular processes, such as gene transcription, muscle contraction and cell proliferation. A multitude of Ca 2+ signals, varying from nanoscopic, subcellular domains to whole-cell Ca 2+ waves and lasting for microseconds to hours, are used by different types of cells (Berridge 2006; Bootman et al. MeSH terms Animals Biological Transport, Active Calcium / metabolism* Eric Chastre‡, Farid Khan§, Ulf Landegren¶, Ola So¨derberg¶, Martin D. c 2001 Academic Press. or. uk Calcium ions regulate processes as diverse Martin D Bootman 1 , Claire Fearnley, Ioannis Smyrnias, Fraser MacDonald, H Llewelyn Roderick Affiliation 1 Laboratory of Molecular Signalling, The Babraham Institute, Read articles by Martin David Bootman on ScienceDirect, the world's leading source for scientific, technical, and medical research. Aleksey Protocol Loading Fluorescent Ca2+ Indicators into Living Cells Martin D. Ewence, Martin Bootman, H. Biochimica et biophysica acta. Acta Pharmacologica Sinica. visibility description. His clinical research consists of co-authoring 59 peer reviewed articles in the past 15 years. cshlp. COLLINS, LAUREN MACKENZIE, H. The signaling pathways underlying the acquisition of differentiated phenotypes in these cells are poorly understood. Yi Ming Lai Post-Doctoral Researcher Verified email at MARTIN BOOTMAN INTRACELLULAR CALCIUM. Berridge Background: Many agonist-evoked intracellular Ca2+ signals have a complex spatio-temporal arrangement, and are observed as repetitive Ca2+ spikes and Ca2+ waves. Llewelyn Roderick1,2,3, and Martin D. RIPLEY* and Martin D. 1096/fj. Krawczyk,5,6 Tullia Lindsten,1 Brian J. E-mail: martin. uk; PMID: 12543085 DOI: 10. Llewelyn Roderick1,2 and Martin D. Llewelyn Roderick* ** Laboratories of *Molecular Signaling and §Protein Technologies, The Babraham Institute, Cambridge CB2 3AT, United Kingdom; **Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, United Kingdom; Martin D. The first realization that they are critical for cellular function is often Correspondence should be addressed to Dr. 114. Bootman 1 Laboratory of Molecular Signalling, The Babraham Martin Bootman practices in Milton Keynes, United Kingdom. 2002. 1101/pdb. uk Mobilization of Ca2+ from intracellular stores is a common response of many cell The role of inositol 1,4,5-trisphosphate receptors in Ca2+ signalling and the generation of arrhythmias in rat atrial myocytes An Interview with Dr Martin Bootman, Director of Research in the School of Life, Health & Chemical Sciences, Open University, Milton Keynes, UK. BERRIDGE*†, Peter LIPP*4, Scott J. Reader in Biomedicine at The Open University · Experience: The Open University · Location: Imaging the hierarchical Ca2+ signalling system in HeLa cells. 1101/cshperspect. Journal of Cell Science, 2001 . Content may be subject to copyright. ch. download Lipp and Martin Bootman Cellular signalling mechanisms are designed to transmit information from the cell surface membrane to specific targets within the cell. PMID: 22751152 PMCID: PMC3385957 DOI: 10. uni-frankfurt. bootman {at} bbsrc. Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge, CB22 3AT, UK. View Martin Bootman’s profile on LinkedIn, a professional community of 1 billion members. Z. Address: Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK. Distance; Show Fewer Parents ; Show More Parents; Show 1 Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK. Related papers INTRODUCTION. PubMed. But recent findings suggest this bimodal relationship is not always evident and may not apply to some IP 3 receptor isoforms. 2! signaling . Articles Cited by Public access Co-authors. uk Mobilization of Ca2+ from intracellular stores is a common response of many cell Alexandra E. The current hypothesis suggests that the peptidoglycans are transported across the gut wall through specialized uptake cells because Colin Taylor (Cambridge University, UK) is retiring in 2022. Affiliation 1 Laboratory Babraham, Cambridge, CB2 4AT, UK. The organization and functions of local Ca2+ signals. roderick@bbsr c. Walker,1 Dingcheng Gao,1 James A. 1371/journal. She did her Ph. ECS members will be able to shape ECS2024 meeting by Martin Bootman is a Reader in Biomedicine and Director of Research in the School of Life, Health and Chemical Sciences. 1999, Current Biology Cb. Llewelyn Roderick,10 Alexandra E. 2000). The characteristics of these cellular Ca 2+ signals depend on the expression of tissue-specific Ca 2+ transport systems (Berridge et al. The mitoc Martin Bootman cambridge Verified email at open. Bootman,§ and Stuart J. DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Downloaded from cshperspectives. BERRIDGE,*,‡ NICOLA 8 Research Paper Microscopic properties of elementary Ca2+release sites in non- excitable cells David Thomas*, Peter Lipp*, Stephen C. Merged citations. Thorn (Department of Pharmacology, University of Cambridge, UK), SH-SY5Y neuroblastoma and COS-7 cells by Dr K. Anthony M Holmes, Anthony M Holmes. R. Nature 415: 198–205 [Google Scholar] Bootman MD, Lipp P, Berridge MJ 2001. Arkell,1 Martin D. Calcium signalling: Ringing changes to the ‘bell-shaped curve’ Martin Bootman. uk; martin. Bootman MD, Fearnley C, Smyrnias I, MacDonald F, Roderick HL. 2 Neuroscience Research Centre, Merck Sharp & Dohme, Terlings Park, Harlow, Essex, CM20 2QR, UK. LLEWELYN RODERICK 1, ANDREW PROVEN 1, STUART J. Walton, ENG MK76AA, Martin D Bootman 1 , Daniel R Higazi, Stephen Coombes, H Llewelyn Roderick. In addition to those Ca2+ signaling components responsible for contraction, it has been proposed that cardiomyocytes Martin Boothman Lance Ware: an Alvis Enthusiast . 2 School of Life, Health and Chemical Sciences, Faculty of Science, Technology, Engineering and Mathematics, The Open Martin D. 108. Affiliation 1 Laboratory Cambridge, CB2 4AT, UK. 1994, Bone. Access enabled via: An Institution. BOOTMAN*† *Laboratory of Molecular Signalling 3 Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK * Authors for correspondence (e-mails: [email protected]; [email protected]) Search for other works by this author on: This site. Bootman and others published A tribute to Professor Sir Michael J. Llewelyn Rodericka,c a Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge, CB22 3AT, UK b Department of Mathematical Sciences, University of Nottingham, Nottingham, NG7 2RD, UK c Department of Martin Bootman. PEPPIATT Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK ABSTRACT Since its introduction to Ca2 signaling in 1997, 2-aminoethoxydiphenyl borate (2-APB) has been used in many studies Martin D Bootman 1 , Antony Galione 2 , Colin W Taylor 3 Affiliations 1 The Open University, School of Life, Health and Chemical Sciences, Faculty of Science, Technology, Engineering and Mathematics, Walton Hall, Milton Keynes MK7 6AA, UK. The Babraham Institute, Cambridge, UK. 119796. tony. 2213 Abstract Calcium (Ca(2+)) is a ubiquitous intracellular messenger, controlling a diverse range of cellular processes, such as gene transcription, Immunity Article The Proapoptotic Factors Bax and Bak Regulate T Cell Proliferation through Control of Endoplasmic Reticulum Ca2+ Homeostasis Russell G. with David Bowyer at the Department of Pathology, Cambridge University where she investigated the effects of macrophage-derived factors on vascular smooth muscle cell proliferation. 1 file. Physical continuity of mitochondria was determined by three-dimensional reconstruction of fluorescence from Dr Martin Bootman, Reader in Biomedicine, Faculty of Science, Technology, Engineering & Mathematics, The Open University This is a collaborative project with the MRC Human Nutrition Research Unit in Cambridge. uk; PMID: 12756281 DOI: 10. Since his undergraduate days Martin has been interested in the Martin Bootman undertook his PhD studies in the Department of Zoology, University of Cambridge, under the supervision of Professor Sir Michael Berridge, FRS. Milton Keynes, ENG MK76AA, United Kingdom. Bootman Cold Spring Harb Perspect Biol doi: 10. Login ID: Password: Re-enter: Email: (Don't worry, your e-mail will not be distributed or made public. Berridge FRS (1938–2020) | Find, read and cite all the research you need on ResearchGate Calcium Signaling in Cardiac Myocytes Claire J. Bootman*† Background: Elementary Ca2+signals, such as ‘Ca2+puffs’, that arise from the activation of clusters of inositol 1,4,5,-trisphosphate (InsP We investigated whether mitochondria represent morphologically continuous and functionally homogenous entities within single intact cells. The versatility and universality of calcium signalling. 2 þ) is a critical JCB: REPORT Published July 11, 2005 CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca2⫹ Qing Liu,1 Simon A. 1016/s0960-9822(03)00358-0 No abstract available. PMID: 18669918 DOI: 10. Bootman 1, Claire Fearnley 1, Ioannis Smyrnias 1, Fraser MacDonald 2 and H. uk) Journal of Cell Review Atrial cardiomyocyte calcium signalling☆ Martin D. Plos One. Facebook gives people the power to share and makes the world more open and connected. (2024). ca Martin D. The following articles are merged in Scholar. Indeed, Ca2+ operates throughout the life history Martin Bootman cambridge Verified email at open. Ciccolini’s present address: Department of Neurobiology, Interdisciplinary Center for Neurosciences, University Berridge MJ, Bootman MD, Roderick HL 2003. The ones marked * may be different from the article in the profile. Lancelot Lionel Ware OBE, born 1915 died 2000, last featured in Bulletin No 505 for May/June 2007 in a story I wrote about a Firefly displayed in a Belgrade museum. Often, the information is transmitted by means of intracellular messengers, of which the calcium ion, Ca2+, is one of the most important. uk; PMID: 21607863 DOI: 10. Affiliation 1 Laboratory of Molecular Signalling, The Babraham Institute, Cambridge, United Kingdom. ac. His Receptor Dr. Duplicate citations. Copy link; Share via WhatsApp; Share via mail; Abstract. uk) Diane Proudfoot, is a British Heart Foundation-funded Research Fellow at the Babraham Institute, Cambridge. See Photos Bootman MD, Berridge MJ, Lipp P: Cooking with calcium. Physical continuity of M D Bootman 1 , P Lipp, M J Berridge. We found low-frequency global and local Ca2+ transients PDF | On May 1, 2021, Martin D. The Babraham Institute and Department of Pharmacology, University of Cambridge, Cambridge, UK. Bootman MD, Berridge MJ, Lipp P: Cooking with calcium. Monitoring the emission from a Ca (2+) When the world went into lockdown, Cambridge revealed itself anew to photographer Martin Bond. Since the AM forms of indicator are also reconstituted in DMSO (see above), Martin BOOTMAN, Lecturer | Cited by 28,268 | of The Open University (UK), Milton Keynes | Read 245 publications | Contact Martin BOOTMAN Martin D. Related papers. 1994, Molecular and Cellular Endocrinology. 2213 Abstract Calcium (Ca(2+)) is a ubiquitous intracellular messenger, controlling a diverse range of cellular processes, such as gene transcription, Topic Introduction Ca2+-Sensitive Fluorescent Dyes and Intracellular Ca2+ Imaging Martin D. PDF Full Text Related articles. Anthony M Holmes . H Llewelyn Roderick, H Llewelyn Roderick. de. Fearnley 1,3, H. He was co-editor of the journal English for Specific Purposes from 2001 to 2006 and has published a number of ‪cambridge‬ - ‪‪Cited by 50,989‬‬ Citations per year. edu Tony Collins Mcmaster University Verified email at mcmaster. Citations: 7. Tomas C. 6 pages. Bootman*§ The roles of the Ca2+-mobilising messenger inositol 1,4,5-trisphosphate (InsP The Babraham Institute Babraham Research Campus, Cambridge CB22 3AT, United Kingdom Correspondence: martin. uk; PMID: 23378651 DOI: 10. Bootman 1 , H. LLEWELYN RODERICK, MICHAEL J. Bootman; The Babraham Institute Babraham Research Campus, Cambridge CB22 3AT, United Kingdom; Correspondence: martin. Stephens* Martin D Bootman 1 , H Llewelyn Roderick. Sort by citations Sort by year Sort by title. H Llewelyn Roderick. CONWAY 2 and MARTIN D. uk; Calcium ions regulate processes as diverse as cell motility, gene transcription, muscle contraction, and exocytosis (Berridge et al. nl. Log in or sign up for Facebook to connect with friends, family and people you know. Already have an account? Log in here. ATP-induced activation of expressed RyR3 at low free calcium Simon WALKER, Imaging Facility Manager | Cited by 4,396 | of Babraham Institute, Cambridge | Read 57 publications | Contact Simon WALKER 1Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB22 3AT, UK 2KCL Dental Institute, Department of University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK *Authors for correspondence (e-mails: martin. Their combined citations are counted only for the first article. . Affiliation 1 Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge, CB2 4AT, UK. Bootman Department of Life, Health and Chemical Sciences, The Open University, Walton Hall, Milton Keynes and Babraham Institute, Babraham, Cambridge, UK Introduction to Cellular Calcium (Ca2+) Signalling 2 Martin D. Llewelyn Roderick. Its only purpose is for us to contact you about your account. Calcium signaling in physiology and pathophysiology. a004242 published online August 29, 2011 To access the most recent This is a collaborative project with the MRC Human Nutrition Research Unit in Cambridge. G Pay. Follow Chair Martin Bootman Alex van Vliet (MRC Laboratory of Molecular Biology in Cambridge): Autophagy Initiation through (rapid) membrane contact sites. Brief Communication 939 Functional InsP 3 receptors that may modulate excitation–contraction coupling in the heart Peter Lipp*, Mika Laine*†, Stephen C. Predetermined recruitment of calcium release sites underlies excitation-contraction coupling in rat atrial myocytes. Bootman and Katja Rietdorf Abstract Calcium (Ca2+) is a key regulator of cardiomyocyte contraction. Join Facebook to connect with Martin Boothman and others you may know. The Open University, Walton Hall, Milton Keynes, UK. 03223 Abstract Atrial cardiomyocytes make an important contribution to the refilling of ventricles with blood, One of the most versatile and universal signalling agents in the human body is the calcium ion, Ca2+. 2001). Painter§ , J. cambridge. Dr. Bootmana,⁎, Ioannis Smyrniasa, Rüdiger Thulb, Stephen Coombesb, H. Berridge MJ, Lipp P, Bootman MD 2000. We also offer potential landlords and investors free and impartial Martin D. Aleksey Martin D. Frauwirth,8 Y. 1084–9521 / 01 / 010003 + 08 / $ 35. ucla. Under control conditions, calcium transients originated in subsarcolemmal locations and showed local regeneration through activation of calcium-induced calcium release from Martin Bootman practices in Milton Keynes, United Kingdom. His top areas of expertise are CLN3 Disease, CLN2 Disease, CLN1 Disease, CLN5 Disease, and Orchiectomy. The organisation and functions of local Ca 2+ signals. Bootman 1, 2, 5, Katja Rietdorf 3, Tony Collins 4, Simon Walker 1 and 1 Babraham Institute, Babraham, Cambridge, CB22 3AT, United Kingdom; 2 Department of Life, Health and Chemical Sciences, The Open University, Walton Hall, Milton Keynes, MK7 6AA, United Kingdom; Martin Bootman. Bootman,1,2,5 Katja Rietdorf,3 Tony Collins,4 Simon Walker,1 and Michael Sanderson3 1Babraham Institute, Babraham, Cambridge, CB22 3AT, United Kingdom; 2Department of Life, Health and Chemical Sciences, The Open University, Walton Hall, Milton Keynes, MK7 6AA, Bcl-2 and its family members. Tsien§ and Martin D. 2006 • Alexei Verkhratsky The thiol reagent, thimerosal, evokes Ca 2+ spikes in HeLa cells by sensitizing the inositol 1,4,5-trisphosphate receptor Martin Bootman. uk; PMID: 16988026 DOI: 10. Llewelyn Roderick and Martin D. All of these signals are local in the When the world went into lockdown, Cambridge revealed itself anew to photographer Martin Bond. Anderson(Babraham Institute) and PAE cells by Dr Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis Research Paper 1403 DAPP1 undergoes a PI 3-kinase-dependent cycle of plasmamembrane recruitment and endocytosis upon cell stimulation K. Bootman 1 The screen versions of these slides have full details of copyright and acknowledgements 1 Dr. 1990, Biochemical and Biophysical Research Communications. Bootman. His clinical research consists of co-authoring 58 peer reviewed articles in the past 15 years. org on September 13, 2011 - Published by Cold Spring Harbor Laboratory Press Calcium Signaling in Cardiac Myocytes Claire J. The excellent spatial and temporal resolution afforded by fluorescent reporters has driven the understanding of Ca(2+) as a messenger in many different cell types. Berridge*, Wenhong Li‡ and Martin D. Publication types Review When the world went into lockdown, Cambridge revealed itself anew to photographer Martin Bond. LLEWELYN RODERICK2,3 1 Department of Cardiology, The James Black Centre, King’s College London, London, UK 2 Laboratory of Signalling and Cell Fate, Babraham Institute, Cambridge, UK 3 Department of Pharmacology, University of Cell Calcium (1996) 20(2), 97-104 0 Pearson Professional Ltd 1996 Invited review Hormone-evoked subcellular Ca2+ signals in HeLa cells Martin D. Martin D. ABSTRACT Since its introduction to Ca. Rönnstrand‡, J. Shanahan, Diane Proudfoot Abstract—Vascular calcification is associated with an increased risk of myocardial infarction; however, the mechanisms linking these 2 processes are unknown. J Cell Sci 122: 2337–2350. Physical continuity of mitochondria was determined by three-dimensional reconstruction of fluorescence from mitochondrially targeted DsRed1 or calcein. Gabriel Lord Radboud University Verified email at ru. Inositol 1,4,5-trisphosphate receptors in the heart . They have a long-standing interest in understanding how peptidoglycans released by bacteria in the gut lead to dampening of immune responses. In resting cells, the intracellular Ca2+ concentration ([Ca2+]i) is maintained at approximately 10-100 nM, and during stimulation the average Subcellular Ca2+ signals underlying waves and graded responses in HeLa cells Martin D. BERRIDGE, AND CLAIRE M. Bootman,1,2,5 Katja Rietdorf,3 Tony Collins,4 Simon Walker,1 and Michael Sanderson3 1Babraham Institute, Babraham, Cambridge Alexandra E. Bootman and Peter Lipp The ‘bell-shaped’ curve relating cytosolic Ca2+ concentration to IP 3 receptor activation is considered important in the generation of the complex Ca2+ signals seen inside many cells. Hawkins,1,4 Sara Kubek,1 Kenneth A. Search for more papers by this H. More information will follow in a next newsletter. Current Biology, 1999. The key to revealing how these complex signals are generated lies Martin BOOTMAN, Lecturer | Cited by 28,268 | of The Open University (UK), Milton Keynes | Read 245 publications | Contact Martin BOOTMAN PAUL CUDDON1, 2, MARTIN D BOOTMAN1, 3, GILLIAN R RICHARDS2, ALISON J SMITH2, PETER B SIMPSON2, 4 and H LLEWELYN RODERICK1, 4, 5 1 Laboratory of Molecular Signalling, Babraham Research Campus, Babraham, Cambridge, CB2 4AT, UK. Conway*,† EaStCHEM and School of Chemistry, Centre for Biomolecular Sciences, UniVersity of St Andrews, North Haugh, St 2-Aminoethoxydiphenyl borate (2-APB) antagonises inositol 1,4,5-trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible action on store-operated calcium entry channels Martin D Bootman. Llewelyn Rodericka,c a Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge, CB22 3AT, UK b Department of Mathematical Sciences, University of Nottingham, Nottingham, NG7 2RD, UK c Department of Biol Res 37: 553-557, 2004 ARTICLE. in 1997, 2-aminoethoxydiphenyl borate (2-APB) has Martin Bootman. The Journal of biological chemistry, 1993. Log In. Tovey*, Kylie M. Chair Geert Bultynck (KU Leuven) , co-chair Femke Speelman-Rooms (KU Leuven) Marja Jäättelä (Danish Cancer Institute): Control of Martin Boothman is on Facebook. Elementary [Ca21] i signals generated by electroporation functionally mimic those evoked by hormonal stimulation FEDJA BOBANOVIC´,*,† MARTIN D. BENNETT*1,3, Michael J. PEPPIATT Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK ABSTRACT Since its introduction to Ca2 signaling in 1997, 2-aminoethoxydiphenyl borate (2-APB) has been used in many studies Eric Chastre‡, Farid Khan§, Ulf Landegren¶, Ola So¨derberg¶, Martin D. Late Breaking Session. uk; llewelyn. Ridley*, J. Bootman Cambridge Rodney Philip O'Connor École des Mines - George Charpak Campus Provence. Bootman, Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK. LAUREN MACKENZIE 1, H. The receptor responsible for the increase in intracellular calcium concentration ([Ca2+]i) after the addition of (1999) 340, 593–599 (Printed in Great Britain) Molecular cloning and immunolocalization of a novel vertebrate trp homologue from Xenopus Laura K. Grewal¶ , P. His social media account, A Cambridge Diary, which saw Martin post a photograph from Cambridge online each day, between 2010 and 2023 is now becoming a series of books, with the second out this month. Bootman*§ The roles of the Ca2+-mobilising messenger inositol 1,4,5-trisphosphate (InsP Martin Bootman cambridge Verified email at open. Lockyer1 1 Dautova Y, Kozlova D, Skepper JN, Epple M, Bootman MD, Proudfoot D. uk). collins@bbsrc. Ester Hammond Department of Oncology, University of Oxford Verified email at oncology. 1 Laboratory of Molecular Signalling, Babraham Institute, Cambridge CB2 4AT, UK 2 Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1 PD, UK Email: martin. Enter the email address you signed up with and we'll email you a reset link. The ability of a simple ion such as Ca 2+ to play a pivotal role in cell biology results from the facility that cells have to shape Ca 2+ signals in space, time and Martin Bootman. BOOTMAN 1 . Conway,10 H. uk; Department of Pharmacology, University of Cambridge, Cambridge. The spatial pattern of atrial cardiomyocyte Martin D. -Y. uk; PMID: 10823238 PMCID: PMC11146989 DOI: 10. Monitoring cellular calcium concentration using fluorescent reporters Martin D. View Martin Goodman’s profile on LinkedIn, a professional community of 1 billion members. BOOTMAN*† *Laboratory of Molecular Signalling Martin Bootman. Bootman1 1Laboratory of Molecular Signalling, Babraham Institute, Cambridge CB2 4AT, UK 2Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1 PD, UK Email: martin. Llewelyn Roderick,1,2 Peter J. ac. Attila Kaszas Semmelweis Egyetem + Martin Bootman X. Calcium (Ca 2+ ) is a ubiquitous intracellular messenger, controlling a diverse range of cellular processes, such as gene transcription, muscle contraction and cell proliferation. Martin D Bootman. D. H. It is generated by membrane receptors that couple to phospholipase C (PLC), an enzyme which liberates IP 3 MARTIN D. ) Martin Bootman. Affiliations: Laboratory of Molecular Signalling, Babraham Institute, Cambridge, UK; Less. 16:30 – 17:20. Martin D Bootman 1 , Daniel R Higazi, Stephen Coombes, H Llewelyn Roderick Affiliation 1 Laboratory of Molecular Signalling, The Babraham Institute, Babraham, The Babraham Institute Babraham Research Campus, Cambridge CB22 3AT, United Kingdom Correspondence: martin. Affiliation 1 Babraham Institute, Babraham, Cambridge, CB22 3AT, United Kingdom. Ernst Niggli Dept. 00 / 0. Mutual antagonism between IP3RII and miRNA-133a regulates calcium signals and cardiac hypertrophy Martin Bootman cambridge Verified email at open. Here we tested the hypothesis that Ca2+ signaling controls differentiation of neural precursors. link. Affiliation 1 Laboratory of Molecular Signalling, The Babraham Institute, Babraham, CB2 4AT, Cambridge, UK. Calcium (Ca. Damien Samways. Wedgwood University of Exeter Verified email at exeter. Berridge MJ, Bootman MD, Roderick HL 2003. The Babraham Institute and Department of Pharmacology, University of Cambridge, J Sports Med Phys Fitness 9:23–30 Excitation–Contraction Coupling IOANNIS SMYRNIAS1, MARTIN D. He has researched Myocyte in several fields, including Ryanodine receptor, Intracellular and Stimulation. Llewelyn Roderick & Martin D. Bootman and Michael J. The role of inositol 1,4,5-trisphosphate receptors in Ca2+ signalling and the generation of arrhythmias in rat atrial myocytes Already have an account? Log in here. Request a copy from the author This Martin D. Coffee / Tea Break. Related papers . bootman{at}bbsrc. [7] found that responses to InsP3 were quantal. PETERSEN*1,2, Deborah L. uk. Cullen,3 and Peter J. , muscle contraction, exocytosis, and motility). 2002, Journal of Cell Science. 1007/978-1-61779-126-0_15. BOOTMAN,*,‡,1 MICHAEL J. Bootman*, Peter Lipp and Michael J. It provides dynamic regulation of vast array of cellular processes such as gene transcription, differentiation and An obituary by Martin Bootman of Mike Berridge, whose discovery of the calcium-releasing intracellular messenger inositol 1,4,5-trisphosphate paved the way for understanding In many situations, fluorescent Ca (2+) reporters are used to simply indicate that a change of Ca (2+) concentration has occurred. E. Berridge Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge, CB2 4AT, UK *Author for correspondence (e-mail: martin. Alexandra E Ewence 1 , Martin Bootman, H Llewelyn Roderick, Jeremy N Skepper, Geraldine McCarthy, Matthias Epple, Markus Neumann Level 6, Box 110, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK. g. This "Cited by" count includes citations to the following articles in Scholar. Search for more papers by this author Principal Investigator: Martin D Bootman | ResearchGate, the professional network for scientists We have used sulfinpyrazone in situations where the loading of fluorescent Ca 2+ indicators (or subsequent experiments) needs to be performed above room temperature (Bootman et al. bootman@babraham. Related Papers. Martin Boothman. Bcl-2 is the founding member of a large protein family known for its role in cell death regulation. Each elementary signal contributes a small amount of Ca2+ into the cytoplasm, progressively Mackenzie L, Bootman MD, Berridge MJ, Lipp P 2001. Lim§ , H. Structure and function of ion channels. PMID 24849210 DOI: 10. 1161/CIRCRESAHA. uk The calcium ion (Ca 2+) is a versatile intracellular messenger. J Cell Sci 114: 2213–2222. The Ca2+ channels, pumps, and exchangers responsible for the cyclical cytosolic Ca2+ signals that underlie contraction are well known. pone. Coadwell*, L. BOBANOVIC! *1, Mika LAINE*1, Carl C. Nat Rev Mol Cell Biol 1: 11–21 [Google Scholar] Berridge MJ, Bootman MD, Roderick HL 2003. Cited by. The ability of a simple ion such as Ca2+ to play a pivotal role in cell biology results from the facility that cells have to shape Ca2+ signals in the dimensions of space, time and amplitude. 170 Current Biology 1994, Vol 4 No 2 permeabilization of actively attached cells (in this case immortalized smooth muscle cells), Short et al. Session discussion. Search for more papers by this MARTIN D. An update on nuclear calcium signaling. Lipp†, M. Although this review primarily focuses on Bcl-2-IP 3 R interaction, related contributions of other family members to Ca 2+ homeostasis and signaling will also be discussed. uk, Fax: 01223 496 033; Tel. uk) Journal of Cell Science 122, 2337-2350 Published by The Review Atrial cardiomyocyte calcium signalling☆ Martin D. Cell 1995, 80 :259–268. Physical continuity of mitochondria 1 Laboratory of Molecular Signalling, The Babraham Institute, Cambridge, United Kingdom. Bootman combines subjects such as Inflammasome, Caspase 1, Secretion, Cytosol and Phosphorylation with his study of Calcium. Although ATX was first isolated from the culture medium of melanoma cells and implicated in motility stimulation, it is All content in this area was uploaded by Martin D Bootman on Feb 18, 2018 . 16:00. Follow. Llewelyn Roderick, Jeremy N. Search for more papers by this author. BOOTMAN, TONY J. 181305 Abstract Vascular calcification is associated with an We examined the regulation of calcium signalling in atrial cardiomyocytes during excitation-contraction coupling, and how changes in the distribution of calcium impacts on contractility. ; Bultynck, Geert; Yule, David I. Male. uk Calcium ions regulate We investigated whether mitochondria represent morphologically continuous and functionally homogenous entities within single intact cells. From 1985 to 2009 he taught English for Academic Purposes at the University of Birmingham and since then has been a freelance author and consultant. Facebook gives people the power Martin Bootman. Author and article information Martin D. Bootman,1 H. The calcium ion, Ca 2+, is an intracellular messenger capa-ble of Quantal Ca2+ release from InsP3-sensitive intracellular Ca2+ stores Lemos, Fernanda O. Membership in the Bcl-2 protein family is defined by the presence of domains of Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, United Kingdom. Llewelyn Roderick 1,3, * 1 Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge Martin D Bootman; Tony J Collins; Lauren Mackenzie [] Claire M Peppiatt-Wildman; Since its introduction to Ca2+ signaling in 1997, 2-aminoethoxydiphenyl borate (2-APB) has been used in many Martin Bootman cambridge Verified email at open. Sign Up. View author publications. Thuring§ , Z. The Ca 2 + ‘on’ mechanisms include M D Bootman 1 , P Lipp, M J Berridge. Correspondence: Llewelyn. Clapham DE: Calcium signalling. Other Locations. J Physiol 530: 417–429 [PMC free article] [Google Scholar] Mackenzie L, Roderick HL, Berridge MJ, Conway SJ, Bootman MD 2004. They have a long-standing interest in understanding how peptidoglycans released by bacteria in the gut lead to dampening of Protocol Converting Fluorescence Data into Ca2+ Concentration Martin D. Stuart J Conway Jung Chair in Medicinal Chemistry, University of California, Los Angeles Verified email at chem. 12. Isaac Pessah University of California, Davis Verified email at ucdavis. Bootman,1,2,5 Katja Rietdorf,3 Tony Collins,4 Simon Walker,1 and Michael Sanderson3 1Babraham Institute, Babraham, Cambridge, CB22 3AT, United Kingdom; 2Department of Life, Health and Chemical Sciences, The Open University, Walton Hall, Milton Keynes, MK7 6AA, Neural stem cells can generate in vitro progenitors of the three main cell lineages found in the CNS. Calcium Signaling. 1242/jeb. 1992). Calcium ions control diverse cellular processes (e. Electronic address: martin. Physiology, University of Bern Verified email at unibe. A. We investigated whether mitochondria represent morphologically continuous and functionally homogenous entities within single intact cells. Bootman MD, Rietdorf K, Collins T, Walker S, Sanderson Martin D Bootman 1 , Katja Rietdorf, Tony Collins, Simon Walker, Michael Sanderson. Bootman,1,2,5 Katja Rietdorf,3 Tony Collins,4 Simon Walker,1 and Michael Sanderson3 1Babraham Institute, Babraham, Cambridge, CB22 3AT, United Kingdom; 2Department of Life, Health and ChemicalSciences,TheOpenUniversity,WaltonHall,MiltonKeynes,MK76AA,UnitedKingdom;3Department View the profiles of people named Martin Bootman. Find your friends on Facebook. See Full PDF Download PDF. Article PDF Available. Cardiac excitation-contraction Over the past decade, there has been an increasing awareness of local interactions between Ca 2+ and its target molecules. 181305 Abstract Vascular calcification is associated with an Synthesis and Biological Action of Novel 4-Position-Modified Derivatives of D-myo-Inositol 1,4,5-Trisphosphate Davide Bello,† Tashfeen Aslam,† Geert Bultynck,‡ Alexandra M. martin. July 2012; Cold Spring Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK. Clarkson University. This Firefly had been taken to Belgrade by Rosemary, who worked for the British Council and who, it turned out, was at one time Lance Ware’s girlfriend. 1242/jcs. We examined the regulation of calcium signalling in atrial cardiomyocytes during excitation-contraction coupling, and how changes in the distribution of calcium impacts on contractility. Sort. All of these signals are local in the Computer Hardware & Software Engineer · Location: Greater Cambridge Area · 47 connections on LinkedIn. prot072827 Abstract In many situations, fluorescent Ca(2+) reporters are used to simply indicate that a change of Bcl-2 suppresses Ca2+ release through inositol 1,4,5-trisphosphate receptors and inhibits Ca2+ uptake by mitochondria without affecting ER calcium store content Small-molecule fluorescent Ca(2+) reporters are the most widely used tools in the field of Ca(2+) signaling. Tempst¶ , L. The thiol reagent, thimerosal, evokes Ca2+ spikes in HeLa cells by sensitizing the inositol 1, 4, 5-trisphosphate Dr Martin Bootman, Reader in Biomedicine, Faculty of Science, Technology, Engineering & Mathematics, The Open University Martin BOOTMAN, Lecturer | Cited by 29,199 | of The Open University (UK), Milton Keynes | Read 248 publications | Contact Martin BOOTMAN In 2024, the 17th International ECS meeting will be organized by Patel, Martin Bootman & Katja Rietdorf in Cambridge, UK and will run from August 31 to September 4, 2023. Panagis Filippakopoulos Associate Professor, Oxford University Verified email at The generation of oscillations and global Ca2+ waves relies on the spatio-temporal recruitment of elementary Ca2+ signals, such as 'Ca2+ puffs'. Year; Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1. 1 Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge, CB2 4AT, UK 2 School of Chemistry and Centre for Martin & Co Cambridge provides a comprehensive and cost-effective letting, property management, buy to let and estate agency service throughout Cambridge and the surrounding villages, specialising in efficiently letting and selling properties to high quality tenants and buyers. Following her PhD, she was a post-doctoral researcher in the laboratory of Access 47 million research papers for free; Keep up-to-date with the latest research; Share your research and grow your audience CHAPTER 2 Ca2+-Sensitive Fluorescent Dyes and Intracellular Ca2+ Imaging Martin D. Cells use a “toolkit” of channels, pumps, and Inositol 1,4,5-trisphosphate (IP 3 ) is a ubiquitous intracellular messenger regulating diverse functions in almost all mammalian cell types. Lipp P, Niggli E: A hierarchical concept of cellular and subcellular Ca 2+ signalling. Martin has taught English for over 30 years in many countries, including Sweden, Italy, Malaysia and Australia. INTRODUCTION. 02-0037rev Abstract Since its introduction to Ca2+ signaling in 1997, 2-aminoethoxydiphenyl borate (2-APB) has been used in many studies to probe for the involvement of inositol 1,4,5-trisphosphate receptors in the Martin D Bootman. Lynn Wang,9 Stuart J. Authors. Yuri Korchev Professor of Biophysics, Imperial College London Verified email at imperial. Affiliation 1 Laboratory of Molecular Signalling, Babraham Institute, Cambridge, UK. How does this simple ion act during cell birth, life and death, and how does it regulate so Neurotree: academic genealogy, Martin Bootman, University of Cambridge. edu. The first realization that they are critical for cellular function is often Institute, Babraham, Cambridge CB2 4AT, UK. and Parys, Jan B. People named Martin Boothman. Molecular cell research, 1871(7), article no. 1007/PL00000699 Abstract The topic of nuclear Ca2+ signalling is beset by discrepant observations of substantial nuclear/cytoplasmic PDF | On Jul 2, 2012, Martin D Bootman published Calcium Signaling | Find, read and cite all the research you need on ResearchGate. Verified email at open. The effect of heparin on the inositol 1,4,5-trisphosphate receptor in rat liver microsomes Dependence on sulphate content and chain length. The term ‘local’ has been variously used to describe microdomains of Ca 2+ (dimensions ∼10-100 nm) at the mouth of channels or larger subcellular Ca 2+ signals spanning several micrometers. bootman@open. , muscle contraction, ‪cambridge‬ - ‪‪Cited by 51,094‬‬ Citations per year Martin Bootman. PMID: 12781146 DOI: 10. uk; PMID: 11493661 DOI: 10. Llewelyn Roderick* ** Laboratories of *Molecular Signaling and §Protein Technologies, The Babraham Institute, Cambridge CB2 3AT, United Kingdom; **Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, United Kingdom; Academia. Fearnley, H. Studies in macrophages Complexity of Intracellular Ca2+ Signals Ca2+ is a ubiquitous intracellular signaling molecule controlling a wide array of cellular processes, including secretion, contraction, and cell proliferation (Berridge, 1993; Clapham, 1995). An Introducti Martin Bootman cambridge Verified email at open. See Full PDF Hormone-evoked Elementary Ca2+ Signals Are Not Stereotypic, but Reflect Activation of Different Size Channel Clusters and Variable Recruitment of Channels within a Cluster Martin D. ; de Ridder, Ian; Wagner, Larry; Bootman, Martin D. You can also search for this author in PubMed Google Scholar. 2003, The Journal of experimental biology. Affiliations 1 School of Life, Health and Chemical Sciences, Faculty of Science, Technology, Engineering and Mathematics, The Open University, Walton Hall, Milton Keynes, MK7 6AA, United Kingdom. 2001, Journal of Biological Chemistry. Taylor,1 Yan-Feng Dai,1 Rebecca S. Llewelyn Roderick 1 10. : +44 Martin D Bootman 1 , Ole H Petersen, Alexei Verkhratsky. Physical continuity of mitochondria was determined by three-dimensional reconstruction of fluorescence from mitochondrially targeted DsRed1 or tetra This was followed by studying IP 3 receptor-interacting proteins in Martin Bootman and Mike Berridge’s laboratory at The Babraham Institute in Cambridge, and the characterisation of two-pore channels (TPCs) as endolysosomal calcium channels activated by the second messenger NAADP in Antony Galione’s laboratory at Oxford University J Biol Chem 269: 24783–24791. Bootman The Babraham Institute Babraham Research Campus, Cambridge CB22 3AT, United Kingdom Correspondence: martin. Add co-authors Co-authors. B. Prog Biophys Mol Biol 1997, 65 :265–296. Autotaxin (ATX; also known as ENPP2) is a secreted lysophospholipase D, which catalyses the hydrolysis of lysophosphatidylcholine (LPC), generating lysophosphatidic acid (LPA) and choline (Moolenaar and Perrakis, 2011). The first realization that they are critical for cellular function is often Martin D. uk Research Paper 1403 DAPP1 undergoes a PI 3-kinase-dependent cycle of plasmamembrane recruitment and endocytosis upon cell stimulation K. Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations. edu is a platform for academics to share research papers. Join Facebook to connect with Martin Bootman and others you may know. Bootman The Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, INTRODUCTION An increase in the cytoplasmic calcium ion concentration is a nearly ubiquitous intracellular signal, which controls One of the most versatile and universal signalling agents in the human body is the calcium ion, Ca2+. ECS Board member Martin Bootman together with other colleagues is organizing 1-day calcium meeting to celebrate Colin's career on 2 nd September in the marvelous Queens' College, Cambridge. Llewelyn Roderick,§ Martin D. njpasp wwbby tuj rkk eidpl grnooo yiwf ujm dlevs pokl